| Title | Chiral diene ligands, a fabrication method thereof and applications thereof |
| Year | 2014 |
| Country | TW、US |
| Inventor | WU, HSYUEH LIANG |
| Co-inventor | Chun-Chih Chen;Chia-Chen Liu;Wei-Ting Wei;Jo-Hsuan Fang |
| Cert. No. | I439441、US8,586,810B2 |
| Introduction | The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene ligand to take part in asymmetric transformations, particularly an asymmetric addition reaction involving a metal catalyst in a basic environment. Most of the products of the reactions implemented by the chiral diene ligands of the present invention have superior optical activity. The method of the present invention comprises a first oxidation step, a saponification step, a second oxidation step, a deprotonation step, and a cross-coupling step. The chiral diene ligand of the present invention is very suitable to be used in the fabrication or synthesis of various chemicals and medical products. |
| Validity | 2032/09/10 |
| Domain | Chemistry |
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